新型柔红霉素和阿霉素类似物的合成及其抗肿瘤活性
Synthesis and antitumour activity of new daunorubicin and adriamycin analogues.
作者信息
Arcamone F, Bernardi L, Patelli B, Giardino P, Di Marco A, Casazza A M, Soranzo C, Pratesi G
出版信息
Experientia. 1978 Oct 15;34(10):1255-7. doi: 10.1007/BF01981401.
PMID:570116
Abstract
A new synthetic procedure for the preparation of daunorubicin and adriamycin analogues bearing different substituents on ring D, has been developed. The new compounds display outstanding efficacy against experimental tumours of mice.
摘要
已开发出一种新的合成方法，用于制备在D环上带有不同取代基的柔红霉素和阿霉素类似物。这些新化合物对小鼠实验性肿瘤显示出卓越的疗效。
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