Badano A R, Miechi H R, Mirkin A, Arcángeli O A, Aparicio N J, Rodríguez A, Oliva A, Turner D, Figueroa Casas P R
Fertil Steril. 1979 Feb;31(2):124-9. doi: 10.1016/s0015-0282(16)43810-0.
Thirty women with secondary amenorrhea and hyperprolactinemia were studied; galactorrhea was present in 25 of them, and 18 were infertile. Serum prolactin (PRL) levels were high in all cases, between 26 and 120 ng/ml. All women were treated with bromocriptine in increasing doses from 2.5 to 5.0 or 7.5 mg daily, according to the response obtained, for 4 months. In 27 patients a PRL determination was performed during treatment; values returned to normal (up to 20 ng/ml) in 23 women and remained high in 4. Galactorrhea disappeared in 21 of 25 women. Ovulatory menses were re-established in 17 patients (56.6%). Seven women became pregnant (38.8%), one of them after bromocriptine and clomiphene were given simultaneously in the same cycle. According to our results and a literature review the following conclusions may be drawn: (1) bromocriptine is a useful therapeutic tool for re-establishing menstruation and inducing ovulation in patients with the hyperprolactinemic-amenorrhea syndrome; (2) the association of bromocriptine and clomiphene could be the next step in the treatment of patients who fail to ovulate with bromocriptine alone.
对30名继发性闭经和高催乳素血症的女性进行了研究；其中25名有溢乳现象，18名不孕。所有病例的血清催乳素（PRL）水平均较高，在26至120 ng/ml之间。所有女性均接受溴隐亭治疗，根据反应情况，剂量从每日2.5毫克逐渐增加至5.0或7.5毫克，持续4个月。27例患者在治疗期间进行了PRL测定；23名女性的PRL值恢复正常（高达20 ng/ml），4名仍保持高水平。25名有溢乳现象的女性中，21名溢乳消失。17例患者（56.6%）恢复了排卵性月经。7名女性怀孕（38.8%），其中1名是在同一周期同时给予溴隐亭和克罗米芬后怀孕的。根据我们的研究结果并结合文献综述，可得出以下结论：（1）溴隐亭是治疗高催乳素血症闭经综合征患者恢复月经和诱导排卵的有效治疗手段；（2）对于单独使用溴隐亭未能排卵的患者，溴隐亭与克罗米芬联合使用可能是下一步的治疗方法。
