de Bernal M, de Villamizar M
Fertil Steril. 1982 Mar;37(3):392-6. doi: 10.1016/s0015-0282(16)46102-9.
Eighteen hyperprolactinemic patients with either amenorrhea or both galactorrhea and amenorrhea were treated with 2.5 mg of bromocriptine per day supplied at night. Ovulation occurred in 16 patients, and 8 wishing to conceive became pregnant. One of these patients became pregnant for a second time at a bromocriptine dose as low as 1.25 mg/day. Normal ovulatory cycles in four women receiving 2.5 mg of bromocriptine per day could also be maintained at 1.25 mg, despite the differences in the degree of prolactin (PRL) inhibition. Progesterone and luteinizing hormone levels measured for both bromocriptine levels were consistent with ovulatory cycles. The low, single dose of bromocriptine per day supplied at night decreased PRL levels, but normalization of blood levels did not always occur. Eighty percent of the patients ovulated with prolactin values over 25 ng/ml (normal value = less than 20 ng/ml).
18名患有高催乳素血症且伴有闭经或同时伴有溢乳和闭经的患者，每晚服用2.5毫克溴隐亭进行治疗。16名患者出现排卵，其中8名希望受孕的患者成功怀孕。其中一名患者在溴隐亭剂量低至1.25毫克/天时再次怀孕。4名每天接受2.5毫克溴隐亭治疗的女性，尽管催乳素（PRL）抑制程度不同，但在1.25毫克剂量时也能维持正常的排卵周期。针对两种溴隐亭水平测量的孕酮和促黄体生成素水平与排卵周期一致。每晚服用低剂量的单剂量溴隐亭可降低PRL水平，但血液水平并非总能恢复正常。80%的患者在催乳素值超过25纳克/毫升（正常值<20纳克/毫升）时排卵。
