鸡胚发育中真皮内胶原蛋白的合成与降解
Synthesis and degradation of collagen in the developing corium of the chick embryo.
作者信息
Boucek R J, Hlavackova V
出版信息
Biochem J. 1968 Dec;110(3):435-40. doi: 10.1042/bj1100435.
Abstract
- Indices of collagen synthesis and degradation were developed in a chick corium system in vitro. 2. These indices were determined by quantitatively measuring non-diffusible and diffusible hydroxy[(14)C]proline in the tissues after a standard period of incubation. 3. Under these incubation conditions collagen metabolism of the corium appears to be stable for at least 180min. 4. The indices of collagen synthesis and degradation seem to reflect the conditions of collagen metabolism in vivo. 5. A rapid collagen turnover occurs in the corium of the 13-14-day embryo owing to an accelerated collagen degradation at that period. 6. Epidermal elements may influence the synthesis as well as the degradation of collagen.
摘要
- 在体外鸡真皮系统中建立了胶原蛋白合成和降解指标。2. 这些指标通过在标准孵育期后定量测量组织中不可扩散和可扩散的羟[(14)C]脯氨酸来确定。3. 在这些孵育条件下，真皮的胶原蛋白代谢似乎至少在180分钟内是稳定的。4. 胶原蛋白合成和降解指标似乎反映了体内胶原蛋白代谢的情况。5. 由于13 - 14天胚胎期胶原蛋白降解加速，其真皮中发生快速的胶原蛋白周转。6. 表皮成分可能影响胶原蛋白的合成以及降解。
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