Parratt J R, Marshall R J
Acta Biol Med Ger. 1978;37(5-6):747-54.
Prostaglandins (PG's) fulfil most of the criteria required for the metabolic "coupler" linking increases in myocardial activity with increases in coronary blood flow. They are synthesized by the heart and coronary vessels, profoundly modify coronary blood flow in low concentrations and are released under conditions of hypoxia and myocardial ischaemia. Studies with inhibitors of PG-synthetase however provide no firm evidence that PG's are involved in the physiological regulation of myocardial blood flow. These studies are reviewed.
前列腺素（PG）符合将心肌活动增加与冠状动脉血流量增加联系起来的代谢“耦合器”所需的大部分标准。它们由心脏和冠状动脉血管合成，在低浓度时能显著改变冠状动脉血流量，并在缺氧和心肌缺血条件下释放。然而，使用PG合成酶抑制剂的研究并未提供确凿证据表明PG参与心肌血流量的生理调节。本文对这些研究进行了综述。
