Karmazyn M, Dhalla N S
Can J Physiol Pharmacol. 1983 Nov;61(11):1207-25. doi: 10.1139/y83-180.
It has now been demonstrated that prostaglandins produce a wide variety of actions on cardiac tissue. These effects are quite complex and are dependent on such factors as type of prostaglandin, animal species, experimental format, as well as the amount of prostaglandin employed. The last factor is of particular concern since the administration of large amounts of prostaglandins may not truly reflect the actual actions of the endogenously synthesized prostaglandins which are likely to be at a very low concentration. In this review we have attempted to analyze the pharmacological properties of prostaglandins on cardiac tissue including coronary arteries and myocardium as well as the subcellular basis for their actions. The possible reasons for the diverse effects of prostaglandins under different experimental conditions have been pointed out. An effort has also been made to synthesize the existing information concerning the actions of prostaglandins on heart in terms of current concepts. A discussion is presented concerning the role of endogenously synthesized prostaglandins in physiological and pathological aspects of cardiac performance and the potential use of prostaglandins and prostaglandin synthesis inhibitors in the treatment of heart disease.
现已证明，前列腺素对心脏组织有多种作用。这些作用相当复杂，取决于前列腺素的类型、动物种类、实验形式以及所用前列腺素的量等因素。最后一个因素尤其值得关注，因为大量使用前列腺素可能无法真实反映内源性合成前列腺素的实际作用，而内源性合成前列腺素的浓度可能非常低。在这篇综述中，我们试图分析前列腺素对包括冠状动脉和心肌在内的心脏组织的药理特性及其作用的亚细胞基础。指出了在不同实验条件下前列腺素产生不同作用的可能原因。我们还努力根据当前概念综合有关前列腺素对心脏作用的现有信息。讨论了内源性合成前列腺素在心脏功能生理和病理方面的作用，以及前列腺素和前列腺素合成抑制剂在心脏病治疗中的潜在用途。
