头孢孟多在婴幼儿及儿童中的药代动力学与安全性
Pharmacokinetics and safety of cefamandole in infants and children.
作者信息
Chang C T, Khan A J, Agbayani M M, Jhaveri R, Amin I, Evans H E
出版信息
Antimicrob Agents Chemother. 1978 Dec;14(6):838-41. doi: 10.1128/AAC.14.6.838.
Abstract
Cefamandole, a new cephalosporin antibiotic, has greater activity against common pathogens, including Escherichia coli, Haemophilus influenzae, and Proteus (including indole-positive strains), than available cephalosporin drugs. We have evaluated the safety and pharmacokinetics of this drug in 30 infants and children. Blood levels and urinary excretion of the drug were similar to those previously found in adults. The only side effects were mild and transient elevation of serum glutamic oxalacetic transaminase in 12 patients and of blood urea nitrogen in 1 patient in whom serum creatinine remained normal and unchanged.
摘要
头孢孟多，一种新型头孢菌素抗生素，对常见病原体，包括大肠杆菌、流感嗜血杆菌和变形杆菌（包括吲哚阳性菌株）的活性比现有头孢菌素药物更强。我们已在30名婴幼儿和儿童中对该药物的安全性和药代动力学进行了评估。该药物的血药浓度和尿排泄情况与先前在成人中发现的情况相似。仅有的副作用是12名患者血清谷草转氨酶轻度短暂升高，1名患者血尿素氮升高，而其血清肌酐保持正常且未发生变化。
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Pharmacokinetics and safety of cefamandole in infants and children.头孢孟多在婴幼儿及儿童中的药代动力学与安全性
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本文引用的文献
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Cefamandole, a cephalosporin antibiotic with an unusually wide spectrum of activity.头孢孟多，一种具有异常广泛活性谱的头孢菌素抗生素。
Antimicrob Agents Chemother. 1974 Aug;6(2):177-82. doi: 10.1128/AAC.6.2.177.
2
Antibiotic susceptibility testing by a standardized single disk method.采用标准化单纸片法进行抗生素敏感性试验。
Am J Clin Pathol. 1966 Apr;45(4):493-6.
3
Simplified, accurate method for antibiotic assay of clinical specimens.临床标本抗生素检测的简化、准确方法。
Appl Microbiol. 1966 Mar;14(2):170-7. doi: 10.1128/am.14.2.170-177.1966.
4
Antibacterial activity of cefamandole, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin, and cephalexin.新型头孢菌素抗生素头孢孟多与头孢噻啶、头孢噻吩和头孢氨苄的抗菌活性比较。
Antimicrob Agents Chemother. 1973 Jun;3(6):657-61. doi: 10.1128/AAC.3.6.657.
5
Clinical pharmacology of cefamandole as compared with cephalothin.头孢孟多与头孢噻吩的临床药理学比较。
Antimicrob Agents Chemother. 1976 Jan;9(1):65-9. doi: 10.1128/AAC.9.1.65.
6
Pharmacological studies with cefamandole in human volunteers.头孢孟多在人体志愿者中的药理学研究。
Antimicrob Agents Chemother. 1976 Jan;9(1):140-4. doi: 10.1128/AAC.9.1.140.
7
Cefamandole: antimicrobial activity in vitro of a new cephalosporin.头孢孟多：一种新型头孢菌素的体外抗菌活性
Antimicrob Agents Chemother. 1975 Dec;8(6):737-41. doi: 10.1128/AAC.8.6.737.
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