Meyers B R, Leng B, Hirschman S Z
Antimicrob Agents Chemother. 1975 Dec;8(6):737-41. doi: 10.1128/AAC.8.6.737.
Cefamandole, a new cephalosporin derivative, was found to have a broad spectrum of activity against a cross-section of both gram-positive and gram-negative bacteria isolated from clinical material. Gram-positive cocci, except for Streptococcus faecalis, were very susceptible. Penicillin G-resistant Staphylococcus aureus also was susceptible to cefamandole. Minimal bactericidal concentrations for gram-positive cocci approximated the minimal inhibitory concentrations. Strains of Haemophilus influenzae were very susceptible to the drug. Most strains of Escherichia coli, Klebsiella sp., and Proteus sp. were inhibited by low concentrations. Increasing resistance occurred with larger inocula. Strains of Pseudomonas sp. were resistant to cefamandole.
头孢孟多，一种新型头孢菌素衍生物，被发现对从临床样本中分离出的多种革兰氏阳性菌和革兰氏阴性菌具有广谱抗菌活性。除粪肠球菌外，革兰氏阳性球菌对其非常敏感。耐青霉素G的金黄色葡萄球菌也对头孢孟多敏感。革兰氏阳性球菌的最低杀菌浓度接近最低抑菌浓度。流感嗜血杆菌菌株对该药非常敏感。大多数大肠杆菌、克雷伯菌属和变形杆菌属菌株可被低浓度药物抑制。接种量大时耐药性增加。铜绿假单胞菌菌株对头孢孟多耐药。
