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[在邻苯三酚存在的情况下，5'-磷酸吡哆醛对离体冠状动脉对肾上腺素反应的影响]

[Influence of pyridoxal-5'-phosphate on the responses of isolated coronary arteries to adrenaline, in the presense of pyrogallol].

作者信息

Bettini V, Legrenzi E, Bologna S

出版信息

Boll Soc Ital Biol Sper. 1978 Aug 30;54(16):1459-63.

PMID:570403
Abstract

The effect of PLP on the adrenaline-induced relaxation of coronary arteries was studied in vitro, after known inhibitor of COMT, Pyrogallol. Relaxation of response to adrenaline were increased by PLP. Pyrogallol potentiated responses of coronary strips to adrenaline and also reduced or abolished the enhancing effects of PLP. It is concluded that PLP enhances the response of coronary smooth muscle to adrenaline by inhibiting a enzymatic pathway for the inactivation of catecholamines.

摘要

在已知的儿茶酚-O-甲基转移酶（COMT）抑制剂连苯三酚存在的情况下，体外研究了磷酸吡哆醛（PLP）对肾上腺素诱导的冠状动脉舒张的影响。PLP可增强对肾上腺素的反应性舒张。连苯三酚增强了冠状动脉条对肾上腺素的反应，同时也降低或消除了PLP的增强作用。结论是PLP通过抑制儿茶酚胺失活的酶促途径来增强冠状动脉平滑肌对肾上腺素的反应。

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