Wiegand S J, Terasawa E, Bridson W E
Endocrinology. 1978 May;102(5):1645-8. doi: 10.1210/endo-102-5-1645.
Very small electrolytic lesions were made over the anterior or posterior portion of the optic chiasm in mature female rats showing normal estrous cycles. Lesions over the posterior portion of chiasm destroyed the suprachiasmatic nucleus of the hypothalamus (SCN) while the anterior lesions destroyed a small neural structure, here designated as the medial preoptic nucleus (MPN). Both lesions were effective in inducing persistent vaginal estrus, but when animals were ovariectomized and treated with exogenous and progesterone it was found that lesions including the MPN alone, but not the SCN alone, eliminated the positive feedback effects of this steroid regimen on LH release.
在具有正常发情周期的成年雌性大鼠的视交叉前部或后部制造非常小的电解损伤。视交叉后部的损伤破坏了下丘脑的视交叉上核（SCN），而前部损伤破坏了一个小的神经结构，这里称为内侧视前核（MPN）。两种损伤均能有效诱导持续性阴道发情，但当动物被切除卵巢并用外源性雌激素和孕酮治疗时，发现仅包括MPN的损伤而非仅SCN的损伤消除了这种类固醇方案对促黄体生成素释放的正反馈作用。
