DI patient refractory to vasopressin and dDAVP: absence of antibodies to AVP and dDAVP and inactivating factor in blood serum.

Antibodies to either AVP or dDAVP were sought in the serum of a patient suffering from diabetes insipidus and treated with Adiuretin (Spofa) to which the patient had become refractory. Neither the antibodies nor the presence of enzymes inactivating LVP was detected in the serum.