Coulon J, Marilley M
J Embryol Exp Morphol. 1978 Dec;48:73-8.
Biochemical assays of adenylate cyclase activity were performed during the early phases of regeneration in Owenia fusiformis (Polychaete Annelid). The results indicate the existence of a strong stimulation in an early phase following trauma. This stimulation is then followed by periodic fluctuations exhibiting a diurnal rhythm correlated with the cell cycle. Adenylate cyclase activity is also shown to be neurotransmitter-dependent. In this paper it is proposed that neurotransmitters might participate in the regulation of cyclic AMP formation, by means of adenylate cyclase acting on target blastema cells, undergoing the cell cycle.
在纺锤欧文蚓(多毛纲环节动物)再生的早期阶段进行了腺苷酸环化酶活性的生化测定。结果表明,创伤后的早期阶段存在强烈的刺激作用。随后这种刺激会伴随着周期性波动,呈现出与细胞周期相关的昼夜节律。腺苷酸环化酶活性也显示出依赖于神经递质。本文提出,神经递质可能通过作用于经历细胞周期的靶芽基细胞的腺苷酸环化酶,参与环磷酸腺苷形成的调节。