Oaknin S, Alonso R, Prieto L, Mas M
Neuroendocrinology. 1979;28(3):196-200. doi: 10.1159/000122862.
Lactate dehydrogenase (LDH) and its isoenzyme (ISO) pattern were measured in the hypothalamus (HYP), amygdala (AMYG), hippocampus (HIP), cerebral cortex and anterior pituitary (PIT) of adult female rats sacrificed at different estrous cycle phases. The HYP, the AMYG and the PIT showed their maximal LDH values at proestrus and the lowest at diestrus. Those of the HIP showed the opposite pattern. The study of the ISO distribution pattern indicated that the cyclic variations of pituitary LDH activity were mainly due to changes of the ISO rich in A subunits, while in the B type they remained constant. By contrast, the cyclic changes of total LDH activity of all the brain structures studied were due to well balanced variations of both A and B subunits.
在处于不同发情周期阶段被处死的成年雌性大鼠的下丘脑（HYP）、杏仁核（AMYG）、海马体（HIP）、大脑皮层和垂体前叶（PIT）中测量乳酸脱氢酶（LDH）及其同工酶（ISO）模式。下丘脑、杏仁核和垂体前叶在发情前期显示出最大的LDH值，在动情间期最低。海马体的情况则相反。对同工酶分布模式的研究表明，垂体LDH活性的周期性变化主要是由于富含A亚基的同工酶的变化，而B型同工酶则保持不变。相比之下，所研究的所有脑结构的总LDH活性的周期性变化是由于A和B亚基的平衡变化。
