Dorfman L J, Bosley T M
Neurology. 1979 Jan;29(1):38-44. doi: 10.1212/wnl.29.1.38.
Somatosensory evoked potential (SEP) latencies, motor and sensory nerve conduction velocities (CVs), and F-wave latenies were measured in 15 elderly normal subjects (mean age 74.1 years), and the results were used to derive indirect estimates of spinal cord CVs. These measurements were compared to those from 15 younger normal adults (mean age 31.6 years), and the nerve conduction characteristics of all 30 subjects were analyzed with respect to age. Peripheral motor and sensory CVs slowed progressively, and the onset latencies of F-waves and SEPs increased gradually with advancing age. Spinal cord CVs showed little change until approximately age 60, and declined sharply thereafter. In addition, the latencies of F-waves and SEPs were positively associated with height. Human clinical and experimental studies utilizing SEP and F-wave measurements must allow for morphologic differences between individuals, and for the systematic changes which accompany normal aging.
在15名老年正常受试者（平均年龄74.1岁）中测量体感诱发电位（SEP）潜伏期、运动和感觉神经传导速度（CV）以及F波潜伏期，并将结果用于间接估计脊髓传导速度。将这些测量结果与15名年轻正常成年人（平均年龄31.6岁）的测量结果进行比较，并分析了所有30名受试者的神经传导特征与年龄的关系。随着年龄的增长，外周运动和感觉传导速度逐渐减慢，F波和SEP的起始潜伏期逐渐增加。脊髓传导速度在大约60岁之前变化不大，此后急剧下降。此外，F波和SEP的潜伏期与身高呈正相关。利用SEP和F波测量的人体临床和实验研究必须考虑个体之间的形态差异以及正常衰老过程中伴随的系统性变化。
