Alvarez E O
Acta Endocrinol (Copenh). 1979 Mar;90(3):434-9. doi: 10.1530/acta.0.0900434.
Previous evidence from our laboratory suggested a possible involvement of prolactin (PRL) in the induction of precocious puberty due to hypothalamic lesions in maturing female rats. In the present report the concentrations of PRL in plasma of lesioned and control rats were determined three times a day at three different periods of puberty. Lesions were produced in 20 day-old rats by a radiofrequency current in the anterior hypothalamic area (AHA). Intact littermates were used as control. Respectively 23, 25 and 28 day-old lesioned and control rats were bled at 08.00, 12.00 or 16.00 h. PRL levels, measured by RIA were determined from plasma aliquots. In control rats, elevated plasma PRL levels were found in the afternoon. Hypothalamic lesion induced a tendency to elevate tonically the PRL plasma concentrations which was evident at 16.00 h in 23 and 25 day-old rats and at 08.00 and 12.00 h in 28 day-old rats. The present results give additional support to our previous suggestion that PRL secretion is modified by the effect of lesions in the AHA.
我们实验室先前的证据表明，催乳素（PRL）可能参与了成熟雌性大鼠因下丘脑损伤而导致的性早熟诱导过程。在本报告中，在青春期的三个不同阶段，每天三次测定损伤大鼠和对照大鼠血浆中的PRL浓度。通过射频电流在下丘脑前部区域（AHA）对20日龄大鼠造成损伤。完整的同窝仔鼠用作对照。分别在08:00、12:00或16:00对23、25和28日龄的损伤大鼠和对照大鼠进行采血。通过放射免疫分析（RIA）从血浆等分试样中测定PRL水平。在对照大鼠中，下午血浆PRL水平升高。下丘脑损伤导致PRL血浆浓度有持续升高的趋势，这在23和25日龄大鼠的16:00以及28日龄大鼠的08:00和12:00时明显。目前的结果进一步支持了我们之前的观点，即AHA损伤会改变PRL的分泌。
