Alvarez E O, Hancke J L, Advis J P
Acta Endocrinol (Copenh). 1977 May;85(1):11-7. doi: 10.1530/acta.0.0850011.
The effects of 2-bromo-alpha-ergocryptine (CB-154) administration in maturing female rats with precocious puberty induced by hypothalamic lesions, as well as the milk secretion rate in these animals after their first parturition were studied. Treatment with CB-154 inhibited precocious vaginal opening induced by hypothalamic lesions. After the treatment with the derivative was terminated, the ovulatory response was not different from that of intact control rats. After their first parturition lesioned rats accumulate milk at a faster rate, following an initial depletion period than their non-operated controls. These results suggest than an alteration in prolactin release may be involved in determining the precocious puberty induced by lesions of the anterior hypothalamic area.
研究了给下丘脑损伤诱导性早熟的成年雌性大鼠注射2-溴-α-麦角隐亭（CB-154）的效果，以及这些动物首次分娩后的泌乳率。CB-154治疗抑制了下丘脑损伤诱导的早熟阴道开口。在终止该衍生物治疗后，排卵反应与完整对照大鼠无异。首次分娩后，损伤大鼠在最初的消耗期后比未手术的对照大鼠更快地积累乳汁。这些结果表明，催乳素释放的改变可能参与了下丘脑前部区域损伤诱导的性早熟的发生。
