Davies H G
J Cell Sci. 1976 Mar;20(2):289-307. doi: 10.1242/jcs.20.2.289.
From quantitative electron-microscope observations on the binding of permanganate to regions of erythrocytes and reticulocytes of known chemical composition, it is concluded that KMnO4, like phosphotungstic acid (PTA), binds preferentially to sites on proteins. Compared with PTA, KMnO4 binding exhibits less anomalous behaviour. The data support the hypothesis previously put forward that the 2 regions, or phases, in condensed chromatin differ in both molecular composition and concentration. The increase in binding to protein which occurs during nuclear haemolysis is interpreted in terms of protein-protein interaction in the chromatin of the intact cell.
通过对高锰酸盐与已知化学成分的红细胞和网织红细胞区域结合的定量电子显微镜观察，得出结论：高锰酸钾与磷钨酸（PTA）一样，优先结合于蛋白质上的位点。与PTA相比，高锰酸钾结合表现出较少的异常行为。这些数据支持了先前提出的假设，即浓缩染色质中的两个区域或相在分子组成和浓度上都有所不同。核溶血过程中与蛋白质结合的增加是根据完整细胞染色质中的蛋白质-蛋白质相互作用来解释的。
