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婴儿疑似恶性高热的处理

Management of suspected malignant hyperpyrexia in an infant.

作者信息

Faust D K, Gergis S D, Sokoll M D

出版信息

Anesth Analg. 1979 Jan-Feb;58(1):33-5. doi: 10.1213/00000539-197901000-00011.

DOI:10.1213/00000539-197901000-00011
PMID:571220
Abstract

A case of possible malignant hyperthermia in a 6-month-old child is presented. Malignant hyperthermia was manifested in this patient by persistent metabolic acidosis in the intraoperative and postoperative periods, by a rapid rise in temperature with concomitant unresponsiveness in the postoperative period, and by a positive caffeine-halothane stimulation test. The malignant hyperthermia occurring in the postoperative period resolved promptly following administration of dantrolene sodium. An unusual aspect of this case is that both of the child's parents had normal CPK values and negative caffeine-halothane stimulation tests.

摘要

本文报告了一例6个月大儿童可能发生恶性高热的病例。该患者的恶性高热表现为术中及术后持续的代谢性酸中毒、术后体温迅速升高并伴有反应迟钝,以及咖啡因-氟烷刺激试验呈阳性。术后发生的恶性高热在给予丹曲林钠后迅速缓解。该病例的一个不寻常之处在于,患儿的父母肌酸磷酸激酶(CPK)值均正常,且咖啡因-氟烷刺激试验均为阴性。

相似文献

1
Management of suspected malignant hyperpyrexia in an infant.婴儿疑似恶性高热的处理
Anesth Analg. 1979 Jan-Feb;58(1):33-5. doi: 10.1213/00000539-197901000-00011.
2
Comparison of the therapeutic effectiveness of a dantrolene sodium solution and a novel nanocrystalline suspension of dantrolene sodium in malignant hyperthermia normal and susceptible pigs.比较丹曲林钠溶液和丹曲林钠新型纳米混悬剂在恶性高热正常和易感猪中的治疗效果。
Eur J Anaesthesiol. 2011 Apr;28(4):256-64.
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Suspected malignant hyperthermia in a 13-month-old: today's "typical" episode--a case report.一名13个月大婴儿疑似恶性高热:今日的“典型”发作——病例报告
AANA J. 1997 Jun;65(3):247-9.
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Markedly delayed postoperative malignant hyperthermia.术后恶性高热明显延迟发作。
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Control of the malignant hyperpyrexic syndrome in MHS swine by dantrolene sodium.
Br J Anaesth. 1975 Jan;47(1):62-5. doi: 10.1093/bja/47.1.62.
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[In vitro diagnosis of malignant hyperpyrexia syndrome].[恶性高热综合征的体外诊断]
Harefuah. 1991 Dec 15;121(12):499-502.
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Porcine malignant hyperthermia: effect of dantrolene sodium on in-vitro halothane-induced contraction of susceptible muscle.猪恶性高热:丹曲林钠对体外氟烷诱导的易感肌肉收缩的影响。
Anesthesiology. 1976 Jan;44(1):57-61.
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Drug treatment of malignant hyperpyrexia.恶性高热的药物治疗。
Anaesth Intensive Care. 1977 Aug;5(3):207-13. doi: 10.1177/0310057X7700500303.
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Malignant hyperthermia: current perspectives.恶性高热:当前观点
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Orally administered dantrolene for prophylaxis of malignant hyperthermia.口服丹曲林预防恶性高热。
Anesthesiology. 1979 Feb;50(2):156-8. doi: 10.1097/00000542-197902000-00016.

引用本文的文献

1
Postoperative malignant hyperthermia and dantrolene therapy.
Can Anaesth Soc J. 1983 Nov;30(6):635-40. doi: 10.1007/BF03015235.
2
Dantrolene.丹曲林
Can Anaesth Soc J. 1984 Jan;31(1):61-75. doi: 10.1007/BF03011484.
3
Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity.丹曲林。对其药效学、药代动力学特性以及在恶性高热、抗精神病药物恶性综合征中的治疗用途的综述,并更新其在肌肉痉挛中的应用。
Drugs. 1986 Aug;32(2):130-68. doi: 10.2165/00003495-198632020-00003.