Powers P J, Cuthbert D, Hirsh J
JAMA. 1979 Jun 1;241(22):2396-7.
In a prospective study to determine the frequency of thrombocytopenia in patients treated with intravenous heparin sodium of porcine gut origin, only four of 120 patients with suspected venous thromboembolism showed a depression of the platelet count to below 150 x 10(9)/L. In two of these patients, heparin was not considered to be the cause of thrombocytopenia because the platelet count, which fell transiently, rose again while heparin therapy was continued. These results indicate that thrombocytopenia is an uncommon complication of anticoagulant therapy with heparin derived from porcine gut mucosa.
在一项前瞻性研究中，为确定接受猪肠源性静脉注射肝素钠治疗的患者中血小板减少症的发生率，120例疑似静脉血栓栓塞的患者中只有4例血小板计数降至150×10⁹/L以下。在其中2例患者中，肝素不被认为是血小板减少症的病因，因为血小板计数虽短暂下降，但在继续肝素治疗时又再次上升。这些结果表明，血小板减少症是猪肠黏膜来源肝素抗凝治疗中一种不常见的并发症。
