Collins R C, Caston T V
Neurology. 1979 May;29(5):705-16. doi: 10.1212/wnl.29.5.705.
Small amounts of penicillin were used to create a seizure focus in the primary visual cortex (area 17), extrastriate cortex (area 18 and 18a), and neighboring somatosensory and temporal areas in rats. Autoradiography with 14C-deoxyglucose was used to map the focus and the local cortical and long subcortical circuits. Mild seizures from area 17 were associated with focal spiking without behavioral manifestations. There was restricted utilization of local U-fiber circuits and ipsilateral subcortical visual system nuclei. Stronger seizures filled up the visual cortex and projected into adjacent neocortex and limbic cortex, the contralateral 17-18a border, and additional subcortical nuclei. Seizures originating in the posterior visual cortex were associated with prolonged afterdischarges and stereotyped behavioral manifestations, with spread into the posterior cingulum, the subicular complex, and the bilateral hippocampus. After analyzing the electrographic discharges, behavior, and seizure pathways in each animal, we conclude that ictal symptoms associated with seizures would not be the expression of the function of a cortical focus, but rather of the dysfunction of excessive discharges through many local and long circuits.
使用少量青霉素在大鼠的初级视觉皮层（17区）、纹外皮层（18区和18a区）以及相邻的体感区和颞区建立癫痫病灶。采用含14C - 脱氧葡萄糖的放射自显影术来描绘病灶以及局部皮层和皮层下长回路。来自17区的轻度癫痫发作与局灶性棘波相关，但无行为表现。局部U纤维回路和同侧皮层下视觉系统核团的利用受限。较强的癫痫发作会波及整个视觉皮层，并投射至相邻的新皮层和边缘皮层、对侧17 - 18a边界以及其他皮层下核团。起源于后视觉皮层的癫痫发作与延长的放电后发放及刻板行为表现相关，并扩散至后扣带回、海马下复合体和双侧海马。在分析每只动物的脑电图放电、行为和癫痫发作途径后，我们得出结论，与癫痫发作相关的发作期症状并非皮层病灶功能的表现，而是通过许多局部和长回路过度放电导致功能障碍的表现。
