Asherov J, Mimouni M, Laron Z
Diabete Metab. 1979 Mar;5(1):1-3.
Widespread subcutaneous lipoatrophy developed in a nineteen year old female diabetic using subcutaneous bovine NPH insulin. Neither rotation of the injection site nor injection of the same insulin into the atrophic areas affected the lesions. Replacement of the bovine insulin by a porcine preparation given by deep intramuscular injection into the center of the atrophic areas resulted in disappearance of the lesions within a short time.
一名19岁的女性糖尿病患者在使用皮下注射牛NPH胰岛素后出现广泛的皮下脂肪萎缩。无论是更换注射部位,还是将相同的胰岛素注射到萎缩区域,均未对病变产生影响。通过在萎缩区域中央进行深部肌肉注射,用猪胰岛素制剂替代牛胰岛素后,病变在短时间内消失。