Schöch G, Winkler K, Heller-Schöch G, Baisch H
Klin Padiatr. 1979 Mar;191(2):197-204.
The qualitative and quantitative analysis by high performance liquid chromatography of the normal and modified nucleobases excreted in urine represents a new and versatile tool. Its use for the diagnosis of malignancies, deliminating infectious diseases, and for the follow-up of the effects of a cytostatic therapy is shown. This method offers a chance to introduce the analysis of a series of fragments of primary gene products into the routine of clinical biochemistry.
通过高效液相色谱法对尿液中排泄的正常和修饰核碱基进行定性和定量分析,是一种新型的通用工具。文中展示了其在恶性肿瘤诊断、传染病鉴别诊断以及细胞抑制疗法效果跟踪方面的应用。该方法为将一系列初级基因产物片段的分析引入临床生物化学常规检测提供了契机。