Jones W E
Am J Trop Med Hyg. 1979 Mar;28(2):300-2. doi: 10.4269/ajtmh.1979.28.300.
In the 5-year period 1973-1977, 43 patients infected with Dipylidium caninum and 43 patients infected with Hymenolepis diminuta were treated with Yomesan (niclosamide) in the dosages recommended by the Parasitic Disease Drug Service, Center for Disease Control. The first post-treatment stool specimen and 1-week and 3-month specimens were examined in 13 patients with D. caninum and 19 patients with H. diminuta. One hundred percent (13/13) of those with D. caninum and 89% (17/19) of those with H. diminuta had negative examinations at 3 months and were considered cured. Two patients with persistent H. diminuta were cured with a second course of drug without changing the dosage or time schedule. Four of these cases had been unresponsive to an initial course of quinacrine hydrochloride. Thus, niclosamide seems to be an effective, relatively nontoxic drug for the initial therapy of these cestode infections.
在1973年至1977年的5年期间，43名感染犬复孔绦虫的患者和43名感染微小膜壳绦虫的患者，按照疾病控制中心寄生虫病药物服务处推荐的剂量，使用氯硝柳胺进行治疗。对13名感染犬复孔绦虫的患者和19名感染微小膜壳绦虫的患者，检查了治疗后的首次粪便标本以及1周和3个月后的标本。感染犬复孔绦虫的患者中有100%（13/13）、感染微小膜壳绦虫的患者中有89%（17/19）在3个月时检查结果为阴性，被视为治愈。2名微小膜壳绦虫持续感染的患者在不改变剂量或时间安排的情况下，通过第二个疗程的药物治愈。其中4例对初始疗程的盐酸奎纳克林无反应。因此，氯硝柳胺似乎是这些绦虫感染初始治疗的一种有效且相对无毒的药物。
