Sulima-Celińska Anna, Kalinowska Alicja, Młocicki Daniel
Department of General Biology and Parasitology, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warsaw, Poland.
W. Stefański Institute of Parasitology, Polish Academy of Science, Twarda 51/55, 00-818 Warsaw, Poland.
Pathogens. 2022 Nov 29;11(12):1439. doi: 10.3390/pathogens11121439.
The tapeworm is a common parasite of the small intestine in rodents but it can also infect humans. Due to its characteristics and ease of maintenance in the laboratory, is also an important model species in studies of cestodiasis, including the search for new drugs, treatments, diagnostics and biochemical processes, as well as its host-parasite interrelationships. A great deal of attention has been devoted to the immune response caused by in the host, and several studies indicate that infection with can reduce the severity of concomitant disease. Here, we present a critical review of the experimental research conducted with the use of as a model organism for over more than two decades (in the 21st century). The present review evaluates the tapeworm as a model organism for studying the molecular biology, biochemistry and immunology aspects of parasitology, as well as certain clinical applications. It also systematizes the latest research on this species. Its findings may contribute to a better understanding of the biology of tapeworms and their adaptation to parasitism, including complex correlations between and invertebrate and vertebrate hosts. It places particular emphasis on its value for the further development of modern experimental parasitology.
绦虫是啮齿动物小肠中的常见寄生虫，但也可感染人类。由于其特性以及在实验室易于饲养，它也是绦虫病研究中的重要模式物种，包括新药研发、治疗方法、诊断手段以及生化过程的研究，还有宿主与寄生虫的相互关系。人们对其在宿主体内引发的免疫反应给予了大量关注，多项研究表明感染该绦虫可减轻伴发疾病的严重程度。在此，我们对二十多年来（21世纪）以该绦虫为模式生物开展的实验研究进行批判性综述。本综述评估了该绦虫作为研究寄生虫学分子生物学、生物化学和免疫学方面以及某些临床应用的模式生物的情况。它还对关于该物种的最新研究进行了系统化梳理。其研究结果可能有助于更好地理解绦虫生物学及其对寄生生活的适应性，包括该绦虫与无脊椎动物和脊椎动物宿主之间的复杂关系。它特别强调了其对现代实验寄生虫学进一步发展的价值。
