含有天冬氨酰甘氨酰序列的肽合成中的副反应。 - Suppr

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Side reactions in the synthesis of peptides containing the aspartyglycyl sequence.

作者信息

Ondetti M A, Deer A, Sheehan J T, Pluscec J, Kocy O

出版信息

Biochemistry. 1968 Nov;7(11):4069-75. doi: 10.1021/bi00851a040.

DOI:10.1021/bi00851a040

PMID:5722271

Abstract

摘要

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Side reactions in the synthesis of peptides containing the aspartyglycyl sequence.含有天冬氨酰甘氨酰序列的肽合成中的副反应。

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Solid-phase method for peptide synthesis using macroreticular copolymers.使用大孔网状共聚物进行肽合成的固相方法。

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引用本文的文献

Spontaneous degradation of polypeptides at aspartyl and asparaginyl residues: effects of the solvent dielectric.天冬氨酸和天冬酰胺残基处多肽的自发降解：溶剂介电常数的影响

Protein Sci. 1993 Mar;2(3):331-8. doi: 10.1002/pro.5560020305.

Isolation and characterization of the intestinal peptide porcine PHI (PHI-27), a new member of the glucagon--secretin family.胰高血糖素-促胰液素家族新成员——肠肽猪PHI（PHI-27）的分离与鉴定

Proc Natl Acad Sci U S A. 1981 Nov;78(11):6603-7. doi: 10.1073/pnas.78.11.6603.

Modifications of the acyl-D-alanyl-D-alanine terminus affecting complex-formation with vancomycin.影响与万古霉素形成复合物的酰基-D-丙氨酰-D-丙氨酸末端修饰

Biochem J. 1971 Aug;123(5):789-803. doi: 10.1042/bj1230789.

The functional dissection of an antigen molecule: specificity of humoral and cellular immune responses to glucagon.抗原分子的功能剖析：对胰高血糖素的体液免疫和细胞免疫反应的特异性

J Exp Med. 1971 Jun 1;133(6):1294-308. doi: 10.1084/jem.133.6.1294.

Stability of protein pharmaceuticals.蛋白质药物的稳定性

Pharm Res. 1989 Nov;6(11):903-18. doi: 10.1023/a:1015929109894.

Chemical pathways of peptide degradation. II. Kinetics of deamidation of an asparaginyl residue in a model hexapeptide.肽降解的化学途径。II. 模型六肽中天冬酰胺残基的脱酰胺动力学。

Pharm Res. 1990 Jul;7(7):703-11. doi: 10.1023/a:1015807303766.

Chemical pathways of peptide degradation. III. Effect of primary sequence on the pathways of deamidation of asparaginyl residues in hexapeptides.肽降解的化学途径。III. 一级序列对六肽中天冬酰胺残基脱酰胺途径的影响。

Pharm Res. 1990 Aug;7(8):787-93. doi: 10.1023/a:1015999012852.

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