免疫抑制剂对小鼠正常噬菌体中和抗体的影响。
Effect of immunosuppressive agents on normal phage-neutralizing antibody in the mouse.
作者信息
Karp R D, Bradley S G
出版信息
J Bacteriol. 1968 Dec;96(6):1931-4. doi: 10.1128/jb.96.6.1931-1934.1968.
The actions of three immunosuppressive drugs on normal antibody synthesis in the adult mouse were determined. Inbred mice were given daily intraperitoneal injections of actinomycin D, uracil mustard, or cyclophosphamide for extended periods. The sera of treated and untreated mice were assayed for phage-neutralizing activity to monitor the effect of each drug on the amount of circulating normal antibody. Except for an initial decrease in titer of normal anti-phage MSP2 activity, actinomycin D had no significant effect on normal antibody activity. Uracil mustard caused alternating elevation and depression of normal antibody titers. Cyclophosphamide caused a prolonged depression of normal antibody. The response patterns to the three immunosuppressive agents were the same for both induced and normal antibody.
测定了三种免疫抑制药物对成年小鼠正常抗体合成的作用。将近交系小鼠长期每日腹腔注射放线菌素D、尿嘧啶氮芥或环磷酰胺。检测经处理和未处理小鼠血清的噬菌体中和活性，以监测每种药物对循环中正常抗体量的影响。除了正常抗噬菌体MSP2活性的效价最初有所下降外，放线菌素D对正常抗体活性没有显著影响。尿嘧啶氮芥导致正常抗体效价交替升高和降低。环磷酰胺导致正常抗体长期降低。诱导抗体和正常抗体对这三种免疫抑制剂的反应模式相同。
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