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抗肿瘤和免疫抑制药物对抗体形成细胞和红细胞生成细胞作用的比较研究。

A comparative study of the effects of anti-tumour and immunosuppressive drugs on antibody-forming and erythropoietic cells.

作者信息

Floersheim G L

出版信息

Clin Exp Immunol. 1970 Jun;6(6):861-70.

PMID:5529340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1712817/
Abstract

Immunosuppressive and erythroid cell line depressing activities of various agents used in cancer chemotherapy were investigated simultaneously in the same mice and compared to X-Rays. Vincristine, vinblastine, mitomycin C and actinomycin D had greater effects on erythropoiesis than on antibody-forming cells. By contrast, the immunosuppressive effects of cyclophosphamide, demecolcine and methotrexate exceeded markedly their erythropoietic toxicity. The Vinca alkaloids stimulated the secondary immune response, whereas X-Rays, antilymphocytic serum and the methylhydrazine derivatives inhibited the anamnestic response to a greater extent than the primary immune response.

摘要

在同一批小鼠中同时研究了癌症化疗中使用的各种药物的免疫抑制和红细胞系抑制活性，并与X射线进行了比较。长春新碱、长春花碱、丝裂霉素C和放线菌素D对红细胞生成的影响大于对抗体形成细胞的影响。相比之下，环磷酰胺、秋水仙胺和甲氨蝶呤的免疫抑制作用明显超过其红细胞生成毒性。长春花生物碱刺激二次免疫反应，而X射线、抗淋巴细胞血清和甲基肼衍生物对回忆反应的抑制程度大于对初次免疫反应的抑制程度。

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本文引用的文献

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Discussion on Clinical and Experimental Studies with Radioactive Iron.
Proc R Soc Med. 1956 Oct;49(10):863-70. doi: 10.1177/003591575604901029.
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IDENTIFICATION OF THE IMMUNE SYSTEM RESPONSIBLE FOR THE SPECIFICITY OF ACTIVELY ACQUIRED TOLERANCE IN MICE.对小鼠主动获得性耐受特异性负责的免疫系统的鉴定。
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DOSE-RESPONSE RELATIONSHIPS FOR AGENTS INHIBITING THE IMMUNE RESPONSE.抑制免疫反应的药物的剂量-反应关系。
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A screen for agents inhibiting the immune response and the growth of tumours.筛选抑制免疫反应和肿瘤生长的因子。
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Erythrocyte Fe59 uptake as a function of bone marrow dose injected in lethally irradiated mice.在致死性照射小鼠中，红细胞铁59摄取量与注射的骨髓剂量之间的函数关系。
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The effect of cytotoxic agents on the production of antibody to T.A.B. vaccine in the mouse.细胞毒性药物对小鼠体内抗伤寒、副伤寒甲和副伤寒乙三联疫苗抗体产生的影响。
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Fe59 uptake measurement of radiation reactions in Swiss mice.瑞士小鼠辐射反应的铁59摄取测量
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Uptake of radioactive iron (59Fe) by nucleated red cells in vitro.体外有核红细胞对放射性铁（59Fe）的摄取。
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Time-dependent immunosuppressive effects of anti-thymocyte serum.抗胸腺细胞血清的时间依赖性免疫抑制作用。
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