Lactate dehydrogenase activity of the rat testis treated with cyproterone acetate during fetal life.

Histological changes, total LDH activity and LDH isozyme patterns of testicular tissues of rats, exposed to cyproterone acetate during fetal life, were studied at different days after birth. While such treated testes revealed all stages of spermatogenesis and normal patterns of LDH isozymes including LDH-X bands, complete loss of isozymes was discernible in the Leydig cell fraction. It is probable that this abnormality in the Leydig cell is a consequence of impairment in the hypothalamo-hypophyseal axis or due to improper scrotal development following CA exposure.