Coulombel L, Tchernia G, Mohandas N
J Lab Clin Med. 1979 Sep;94(3):467-74.
A comparative study of circulating human reticulocytes by phase-contrast microscopic observation and NMB staining revealed two different forms of reticulocytes which could be clearly distinguished by their distinctive morphologic appearance. These were (1) a multilobular motile form and (2) a cup-shaped nonmotile form. Sequential studies of different populations in the circulation of newborns showed that the multilobular form was the youngest and the cup-shaped form the more mature reticulocyte. The multilobular form was found in the circulation only under conditions of erythropoietic stress and could not be detected in the circulation of hematologically normal individuals. The presence of these characteristic forms in peripheral blood can be used as a reliable indicator of transient or persistent erythropoietic stress.
通过相差显微镜观察和奈米比亚锥虫蓝染色对循环中的人类网织红细胞进行的比较研究显示，网织红细胞有两种不同形式，可通过其独特的形态外观清晰区分。这两种形式分别是：（1）多叶运动型和（2）杯状非运动型。对新生儿循环中不同群体的连续研究表明，多叶型是最年轻的网织红细胞，杯状型是更成熟的网织红细胞。多叶型仅在红细胞生成应激条件下出现在循环中，在血液学正常个体的循环中无法检测到。外周血中这些特征性形式的存在可作为短暂或持续红细胞生成应激的可靠指标。
