Krivosheĕv O G, Siutkin E A, Badosov E P, Isachenkov V A
Probl Endokrinol (Mosk). 1979 Jul-Aug;25(4):56-60.
The changes in the luteinizing hormone (LH) level in the pineal gland were studied in rats depending on their sex and age, and under conditions of hypophysectomy or gonadectomy. In golden hamsters these changes were studied during the sexual cycle. The LH level was determined by the radioimmunological method. The gonadotropin content in animals aged under 15 days was independent of sex. At the age of 23 days the LH content was greater in the female animals than in the male, whereas in 30- and 60-day female rats it was decreased in comparison with that in the male animals. The LH concentration (per 1 mg of protein) was maximal in the pineal gland extracts of 5-day male and female rats. Gonadectomy of rats led to an approximately double elevation of the LH content in the pineal gland on the 13th postoperative day both in male and female rats. This index was restored to control values three weeks after the operation. From the onset to the termination of diestrus in hamsters the LH content in the pineal gland decreased from 215 to 75 pg/organ, and after diestrus followed by proestrus and estrus it rose to 180 pg/organ (P less than 0.05). A reduction of the LH content to the 10th postoperative day followed hypophysectomy in male and female pubertant rats; the gonadotropin content was restored in two weeks.
研究了大鼠松果体中促黄体生成素（LH）水平随性别、年龄以及垂体切除或性腺切除情况的变化。在金黄仓鼠中，研究了其在性周期中的这些变化。通过放射免疫法测定LH水平。15日龄以下动物的促性腺激素含量与性别无关。23日龄时，雌性动物的LH含量高于雄性，而在30日龄和60日龄的雌性大鼠中，与雄性动物相比其LH含量降低。5日龄雄性和雌性大鼠松果体提取物中的LH浓度（每1毫克蛋白质）最高。大鼠性腺切除术后第13天，雄性和雌性大鼠松果体中的LH含量均升高约两倍。该指标在术后三周恢复至对照值。从仓鼠间情期开始到结束，松果体中的LH含量从215皮克/器官降至75皮克/器官，间情期后接着是发情前期和发情期，其含量升至180皮克/器官（P小于0.05）。青春期雄性和雌性大鼠垂体切除后，LH含量在术后第10天降低；促性腺激素含量在两周内恢复。
