Nanninga L B
Thromb Haemost. 1979 Apr 23;41(2):357-64.
The fibrinolytic effect of diiodosalicylate was expressed as apparent units urokinase. The dissociation constant of the urokinase-inhibitor complex is increased 19 times in the presence of 10(-2) M diiodosalicylate. The binding of diiodosalicylate to the antiactivator was estimated and the increase in free urokinase in the presence of diiodosalicylate was calculated. With 10(-2) M diiodosalicylate present only 4% of the inhibitor remains free to bind urokinase. Therefore, the fibrinolytic action of diiodosalicylate can be explained on the basis of its binding to the inhibitor and the release of free urokinase.
二碘水杨酸的纤溶作用以表观尿激酶单位表示。在存在10⁻² M二碘水杨酸的情况下，尿激酶 - 抑制剂复合物的解离常数增加了19倍。估算了二碘水杨酸与抗激活剂的结合，并计算了在二碘水杨酸存在下游离尿激酶的增加量。当存在10⁻² M二碘水杨酸时，只有4%的抑制剂仍可自由结合尿激酶。因此，二碘水杨酸的纤溶作用可以基于其与抑制剂的结合以及游离尿激酶的释放来解释。
