Srivastava V M, Dube B, Dube R K, Agarwal G P, Ahmad N
Thromb Haemost. 1981 Jun 30;45(3):252-4.
Fibrinolytic activity as well demonstrable in the blood of Rana tigrina. There occurs prompt lysis of diluted plasma; and the plasma euglobulin fraction shows lysis on both unheated and heated fibrin (human or bovine) plates, implying the presence of plasmin-like enzyme in this fraction. The fibrinolytic activity is remarkably inhibited by the erythrocyte-lysate and is moderately enhanced by leucocytes-thrombocytes. EACA suppresses the lysis of dilute cell-free plasma clots at concentrations of 10(-4) M or more, possibly indicating the presence of plasminogen activator in the plasma. Activation of fibrinolysis by human urokinase and not by streptokinase, shows the probable presence of plasminogen and absence of proactivator.
在虎纹蛙的血液中也可证实有纤维蛋白溶解活性。稀释血浆会迅速溶解;血浆优球蛋白部分在未加热和加热的纤维蛋白(人或牛)平板上均显示溶解,这意味着该部分存在类纤溶酶。纤维蛋白溶解活性受到红细胞裂解物的显著抑制,并受到白细胞 - 血小板的适度增强。在浓度为10(-4)M或更高时,EACA抑制无细胞稀释血浆凝块的溶解,这可能表明血浆中存在纤溶酶原激活剂。人尿激酶而非链激酶可激活纤维蛋白溶解,这表明可能存在纤溶酶原且不存在前激活剂。