Tinkelman D, Vanderpool G, Carroll M S, Spangler D L
Ann Allergy. 1979 Sep;43(3):155-9.
Twenty-one adult chronic asthmatic patients were studied while taking a 12-hour sustained-action theophylline tablet. Pulmonary function testing and serum theophylline levels were monitored for 12 weeks, including testing every two hours over one dosing interval on the final day of the study. Results indicate the preparation tested produced sustained stable theophylline levels for a full 12 hours, with pulmonary function also remaining elevated and stable during this period. There was minimal toxicity reported over the 12-week period and no evidence of tolerance.
对21名成年慢性哮喘患者服用12小时长效茶碱片的情况进行了研究。在12周内监测肺功能测试和血清茶碱水平，包括在研究最后一天的一个给药间隔内每两小时进行一次测试。结果表明，所测试的制剂在整整12小时内产生了持续稳定的茶碱水平，在此期间肺功能也保持升高和稳定。在12周期间报告的毒性极小，且没有耐受性的证据。
