Hodgkinson D J, Soule E H, Woods J E
Cancer. 1979 Sep;44(3):1106-13. doi: 10.1002/1097-0142(197909)44:3<1106::aid-cncr2820440345>3.0.co;2-c.
Between 1920 and 1970, 13 patients (7 men and 6 women) with cutaneous angiosarcomas of the head or neck were treated at the Mayo Clinic; the mean age of the patients was 66 years. Three clinical patterns were noted: a superficial spreading type, a nodular type, and an ulcerating type. There were no predisposing benign lesions; however, in one patient, angiosarcoma developed in an area of previously irradiated skin. Three modes of therapy were used: surgery alone, radiation alone, and surgery with postoperative irradiation. Of the 13 patients, 2 survived more than 5 years and 2 were alive within 1 year of therapy. Because cervical lymph node spread is common, lymph node clearance is recommended for patients with lateralized lesion or with palpable lymphadenopathy at presentation.
1920年至1970年间，梅奥诊所收治了13例头颈部皮肤血管肉瘤患者（7例男性，6例女性）；患者的平均年龄为66岁。观察到三种临床类型：浅表扩散型、结节型和溃疡型。没有易患的良性病变；然而，有1例患者的血管肉瘤发生在先前接受过放射治疗的皮肤区域。采用了三种治疗方式：单纯手术、单纯放疗以及手术加术后放疗。13例患者中，2例存活超过5年，2例在治疗后1年内仍存活。由于颈部淋巴结转移很常见，对于初诊时病变局限于一侧或可触及淋巴结肿大的患者，建议进行淋巴结清扫。
