Cochran J H, Fee W E
Otolaryngol Head Neck Surg (1979). 1979 Jul-Aug;87(4):409-16. doi: 10.1177/019459987908700403.
Angiosarcomas are uncommon tumors of the skin and soft tissues, but occur in endothelial cells of almost any internal organ. When they occur in the skin, the head and neck are the most common sites of origin. Nothing is pathognomonic about their clinical presentation, and the pathologic diagnosis can only be established by biopsy. The frequent multicentric nature of the tumor and propensity for extensive subcutaneous spread require wide treatment fields, whatever the modality of therapy, and account for the low survival reported. Four cases and their outcome are reported, with only one patient achieving an apparent cure following irradiation therapy. Based on experience and extensive review of the literature, a best therapeutic approach cannot be recommended. Since the outlook for cure is so unfavorable, there appears to be a need for cooperative studies using surgery, irradiation, and perhaps, chemotherapy.
血管肉瘤是皮肤和软组织的罕见肿瘤，但几乎可发生于任何内脏器官的内皮细胞。当发生于皮肤时，头颈部是最常见的起源部位。其临床表现无特异性，病理诊断只能通过活检来确立。肿瘤多中心发生的特性以及广泛皮下扩散的倾向，无论采用何种治疗方式，都需要广阔的治疗范围，这也是报道的生存率低的原因。本文报告了4例患者及其治疗结果，只有1例患者在放疗后获得明显治愈。基于经验和对文献的广泛回顾，无法推荐最佳治疗方法。由于治愈前景不佳，似乎需要开展使用手术、放疗以及可能的化疗的合作研究。
