Kaiya H
Folia Psychiatr Neurol Jpn. 1979;33(2):223-32. doi: 10.1111/j.1440-1819.1979.tb00194.x.
In order to show the fine structure of target neurons of antischizophrenic drugs in the neostriatum, acetylcholinergic neurons were identified by means of choline acetyltransferase (ChAc) and acetylcholinesterase (AChE) cytochemistry. Two types of neurons were revealed to have ChAc activity and at the same time to be synthesizing sites of AChE. It was observed that both types of neuron receive boutons containing ChAc positive synaptic vesicles at the soma and/or the dendrite. Moreover, both types of neuron were revealed to be postsynaptic sites of dopaminergic synapses from the fact that degenerated boutons after coagulation of the substantia nigra and boutons containing granular synaptic vesicles after incubation with alpha-methylnoradrenaline, contact the soma of the cholinergic neurons. It is speculated that both cholinergic neurons may be reciprocally influenced as in the case of motor neurons and Renshaw cells in the spinal anterior horn.
为了显示抗精神分裂症药物在新纹状体中的靶神经元的精细结构，通过胆碱乙酰转移酶（ChAc）和乙酰胆碱酯酶（AChE）细胞化学方法鉴定了乙酰胆碱能神经元。发现有两种类型的神经元具有ChAc活性，同时也是AChE的合成部位。观察到这两种类型的神经元在其胞体和/或树突处均接受含有ChAc阳性突触小泡的终扣。此外，从黑质凝固后出现的变性终扣以及用α-甲基去甲肾上腺素孵育后含有颗粒突触小泡的终扣与胆碱能神经元的胞体相接触这一事实来看，这两种类型的神经元均被揭示为多巴胺能突触的突触后部位。据推测，这两种胆碱能神经元可能像脊髓前角运动神经元和闰绍细胞那样相互影响。
