急性无菌性脑膜炎患者脑脊液中寡克隆免疫球蛋白与HLA抗原之间无关联。

No association between oligoclonal immunoglobulins in cerebrospinal fluid and HLA antigens in acute aseptic meningitis.

作者信息

Frydén A, Möller E, Link H

出版信息

Neurology. 1979 Oct;29(10):1422-3. doi: 10.1212/wnl.29.10.1422.

DOI:10.1212/wnl.29.10.1422

Abstract

The frequencies of the HLA antigens A3, B7, and Dw2, previously related with multiple sclerosis, were investigated in 26 patients with acute aseptic meningitis and oligoclonal immunoglobulins in cerebrospinal fluid (CSF), but not in serum when investigated by agarose gel electrophoresis. HLA antigen frequencies were similar in patients with aseptic meningitis and controls. The oligoclonal immune response within the central nervous system in aseptic meningitis is not associated with the same HLA antigens found in patients with multiple sclerosis.

摘要

对先前发现与多发性硬化症相关的HLA抗原A3、B7和Dw2的频率进行了研究，研究对象为26例急性无菌性脑膜炎患者，这些患者脑脊液（CSF）中有寡克隆免疫球蛋白，但经琼脂糖凝胶电泳检测血清中未发现。无菌性脑膜炎患者的HLA抗原频率与对照组相似。无菌性脑膜炎中枢神经系统内的寡克隆免疫反应与多发性硬化症患者中发现的相同HLA抗原无关。