Forbes A R, Gamsu G
Anesth Analg. 1979 Sep-Oct;58(5):387-9. doi: 10.1213/00000539-197909000-00008.
It has previously been demonstrated that an induction dose of thiopental, 25 mg/kg, without continuing anesthesia did not depress peripheral lung mucociliary clearance in the dog, whereas 2 hours of anesthesia with halothane, 1.2 MAC, did depress clearance. To determine whether this was because thiopental depresses the mucociliary apparatus less than halothane, this study compared mucociliary clearance after 2 hours of anesthesia with halothane with clearance after 2 hours of anesthesia with thiopental, 40 mg/kg. With thiopental, 40 mg/kg, 50% mucociliary clearance of tantalum from peripheral airways required 280 +/- 65 (SEM) minutes, which was comparable to clearance obtained with halothane, 1.2 MAC, 382 +/- 27 (SEM) minutes. Hence thiopental depresses mucociliary clearance as much as halothane does when both are administered in equivalent anesthetic doses for equal periods of time.
先前已经证明，给予25mg/kg的硫喷妥钠诱导剂量，且不持续麻醉，并不会抑制犬外周肺的黏液纤毛清除功能，而使用1.2MAC的氟烷麻醉2小时则会抑制清除功能。为了确定这是否是因为硫喷妥钠对黏液纤毛装置的抑制作用小于氟烷，本研究比较了使用1.2MAC氟烷麻醉2小时后的黏液纤毛清除功能与使用40mg/kg硫喷妥钠麻醉2小时后的清除功能。使用40mg/kg硫喷妥钠时，外周气道钽的50%黏液纤毛清除需要280±65（标准误）分钟，这与使用1.2MAC氟烷时的清除时间382±27（标准误）分钟相当。因此，当以等效麻醉剂量给药相同时间时，硫喷妥钠对黏液纤毛清除功能的抑制作用与氟烷相同。
