Forbes A R
Anesthesiology. 1976 Jul;45(1):59-63. doi: 10.1097/00000542-197607000-00010.
Tracheal mucociliary flow rates in dogs were measured with a radioactive droplet technique during thiopental anesthesia, and subseqently during halothane anesthesia. Body temperature and inspired gas temperature and humidity were held constant. Ventilation was controlled with 25 per cent oxygen in nitrogen to produce PaCO2 30 torr. Mucociliary flow rate remained constant when halothane concentration was held constant at 1.2 MAC halothane. Mucociliary flow rates at 0.6 MAC halothane were comparable to those after thiopental, 25 mg/kg. Increases in concentration from 0.6 to 1.2 to 1.8 to 2.4 MAC halothane progressively depressed mucociliary flow. Flow at 2.4 MAC halothane was 27 per cent of the control (thiopental) value. Flow returned to previous values as end-tidal halothane concentration was reduced. The depression produced by halothane may represent impairment of an important pulmonary defense mechanism.
在硫喷妥钠麻醉期间，随后又在氟烷麻醉期间，采用放射性微滴技术测量了犬的气管黏液纤毛流速。体温、吸入气体的温度和湿度保持恒定。用氮气中25%的氧气控制通气，以使动脉血二氧化碳分压维持在30托。当氟烷浓度维持在1.2倍最低肺泡有效浓度（MAC）时，黏液纤毛流速保持恒定。0.6倍MAC氟烷时的黏液纤毛流速与25毫克/千克硫喷妥钠后的流速相当。氟烷浓度从0.6倍MAC增加到1.2倍MAC、再到1.8倍MAC、最后到2.4倍MAC时，黏液纤毛流速逐渐降低。2.4倍MAC氟烷时的流速为对照（硫喷妥钠）值的27%。随着呼气末氟烷浓度降低，流速恢复到先前的值。氟烷引起的这种降低可能代表一种重要肺防御机制的损害。
