Halbreich U, Grunhaus L, Ben-David M
Arch Gen Psychiatry. 1979 Oct;36(11):1183-6. doi: 10.1001/archpsyc.1979.01780110037004.
Twenty-four-hour rhythms of serum prolactin (PRL) levels were studied in seven depressive patients. Blood was collected through an indwelling catheter and the PRL level was determined by homologous double antibody radioimmunoassay. Findings showed a different pattern of secretion of prolactin among depressives as compared to the normal 24-hour rhythm of the hormone. A statistically significant elevation of PRL levels during the evening, several hours before sleep, was found. Morning PRL levels were slightly higher and the average increase of PRL level from one determination to the consecutive one was higher among the depressives. It is assumed that there may be a connection between the diurnal rhythmicity of mood, characteristic of vital depression, and the different 24-hour rhythmicity of PRL level.
对7名抑郁症患者的血清催乳素（PRL）水平的24小时节律进行了研究。通过留置导管采集血液，并采用同源双抗体放射免疫分析法测定PRL水平。研究结果显示，与该激素正常的24小时节律相比，抑郁症患者的催乳素分泌模式有所不同。发现在晚上睡眠前几个小时，PRL水平有统计学意义的升高。抑郁症患者早晨的PRL水平略高，且从一次测定到下一次连续测定的PRL水平平均升高幅度更大。据推测，重度抑郁症所特有的情绪昼夜节律与PRL水平不同的24小时节律之间可能存在联系。
