Linkowski P, Kerkhofs M, Van Onderbergen A, Hubain P, Copinschi G, L'Hermite-Balériaux M, Leclercq R, Brasseur M, Mendlewicz J, Van Cauter E
School of Medicine, Université Libre de Bruxelles, Belgium.
Arch Gen Psychiatry. 1994 Aug;51(8):616-24. doi: 10.1001/archpsyc.1994.03950080028004.
To characterize sleep and the 24-hour profiles of cortisol, prolactin (PRL), and growth hormone (GH) secretion in mania.
Blood was sampled at 15-minute intervals, and sleep was polygraphically recorded in eight unmedicated male patients with pure mania and the results compared with those from a group of 14 healthy age-matched controls. The circadian, sleep-related, and pulsatile hormonal variations were quantitatively characterized using specifically designed computer algorithms.
The manic state was associated with alterations of corticotropic activity and circadian rhythmicity partially overlapping those previously observed in acute endogenous depression, consisting of an elevation of nocturnal cortisol levels and an early timing of the nadir of the circadian variation. Sleep onset was delayed and the sleep period was reduced. A trend for short rapid eye movement latencies was apparent in the adult patients. Both the amount and the temporal organization of PRL and GH secretion were normal.
The manic state seems to be characterized by similar but less severe neuroendocrine and circadian abnormalities, compared with major depression.
描述躁狂症患者的睡眠情况以及皮质醇、催乳素（PRL）和生长激素（GH）分泌的24小时变化规律。
对8名未用药的单纯躁狂男性患者每隔15分钟采集一次血液样本，并通过多导睡眠图记录其睡眠情况，将结果与14名年龄匹配的健康对照者进行比较。使用专门设计的计算机算法对昼夜节律、睡眠相关和脉冲性激素变化进行定量描述。
躁狂状态与促肾上腺皮质激素活性和昼夜节律的改变有关，部分与先前在急性内源性抑郁症中观察到的情况重叠，包括夜间皮质醇水平升高和昼夜变化最低点时间提前。入睡延迟，睡眠时间缩短。成年患者中快速眼动潜伏期缩短的趋势明显。PRL和GH分泌的量和时间组织均正常。
与重度抑郁症相比，躁狂状态似乎具有相似但程度较轻的神经内分泌和昼夜节律异常特征。
