Verlangieri A J
Pharmacol Biochem Behav. 1979 Jul;11(1):95-8. doi: 10.1016/0091-3057(79)90303-4.
Prenatal and postnatal chronic lead intoxication was induced in Wistar rats with 0.1 mg/ml PbCl2 in the drinking water of pregnant and lactating females. Offspring were supplied lead water at weaning. Exposure totaled 14 months. Activity was measured in the Wahman LC-33 wheel. Running activity in experimental and control rats was maximized with a 23-hr light cycle followed by a 5-hr dark period in the wheels. There was no significant difference in body weight gains or lead intake (as measured by water consumption) between any sex-matched group. Lead was found to produce overall hypoactivity in both males and females. Under auditory stress the hypoactivity in the males was normalized by combination of a hypoactivity component in the controls and a progressive hyperactivity in the lead animals. This study clearly shows a sex-dependent hypoactivity effect of chronic lead intoxication and suggests its mechanism as an interaction between lead and environmental stress.
在怀孕和哺乳期雌性Wistar大鼠的饮用水中加入0.1毫克/毫升的氯化铅，诱导其出现产前和产后慢性铅中毒。后代在断奶时开始饮用含铅水。暴露期总计14个月。在Wahman LC - 33转轮中测量活动情况。实验大鼠和对照大鼠的跑步活动在转轮中采用23小时光照周期和5小时黑暗周期时达到最大值。在任何性别匹配组之间，体重增加或铅摄入量（通过饮水量测量）均无显著差异。发现铅会导致雄性和雌性大鼠整体活动减少。在听觉应激下，雄性大鼠的活动减少通过对照组中活动减少成分与铅处理组中逐渐增加的活动亢进相结合而恢复正常。这项研究清楚地表明了慢性铅中毒对活动减少的性别依赖性影响，并提示其机制为铅与环境应激之间的相互作用。
