Rafales L S, Bornschein R L, Michaelson I A, Loch R K, Barker G F
Pharmacol Biochem Behav. 1979 Jan;10(1):95-104. doi: 10.1016/0091-3057(79)90174-6.
Three interrelated studies were conducted to examine the locomotor activity of lead-exposed mice. The effects of lead were examined as a function of the dose and duration of exposure. Exposure during the first three weeks occurred via the maternal milk supply. Exposure following weaning was achieved via the water supply. Mice received challenges with various pharmaceutical agents, including d-amphetamine, methylphenidate, apomorphine and phenobarbital. The spontaneous activity prior to injection and the drug-induced activity were monitored. Lead-exposed mice usually displayed spontaneous activity which was indistinguishable from that of the control animals. In only one set of observations did lead exposure result in a modest increase in spontaneous activity. The drug-induced activity varied in a complex manner as a function of the magnitude and duration of the lead exposure. Depressed body weight, which was concurrent with high lead exposure (0.5% Pb(Ac)2) was also a significant parameter affecting both the spontaneous and drug-induced activity.
进行了三项相互关联的研究，以检查铅暴露小鼠的运动活性。研究了铅的影响与暴露剂量和持续时间的关系。前三周的暴露通过母乳供应实现。断奶后的暴露通过饮水供应实现。小鼠接受了包括右旋苯丙胺、哌醋甲酯、阿扑吗啡和苯巴比妥在内的各种药剂的刺激。监测注射前的自发活动和药物诱导的活动。铅暴露小鼠通常表现出与对照动物无法区分的自发活动。仅在一组观察中，铅暴露导致自发活动适度增加。药物诱导的活动随铅暴露的程度和持续时间而以复杂的方式变化。与高铅暴露（0.5%醋酸铅）同时出现的体重减轻也是影响自发活动和药物诱导活动的一个重要参数。
