Coquelin A, Bronson F H
Science. 1979 Nov 30;206(4422):1099-101. doi: 10.1126/science.573924.
Male mice release luteinizing hormone when exposed for a short time to a female. In this experiment, multiple blood samples were withdrawn by atrial cannulas from tethered males during either continuous or intermittent exposure to nonreceptive females. After an immediate, transient release of luteinizing hormone, continuous exposure to the same female was accompanied by only random, spontaneous elevations in plasma levels of this hormone. Successive presentations of the same female at 2-hour intervals elicited gradually diminishing luteinizing hormone responses. Exposing such unresponsive males to novel, diestrous females, however, dramatically stimulated their release of the hormone. These results demonstrate habituation of a socially induced, neuroendocrine response involving reproductive hormones.
雄性小鼠在短时间接触雌性时会释放促黄体生成素。在本实验中，通过心房插管从被束缚的雄性小鼠身上采集多个血样，这些雄性小鼠处于持续或间歇性接触无接受能力的雌性小鼠的状态。在促黄体生成素立即出现短暂释放后，持续接触同一只雌性小鼠时，该激素的血浆水平仅出现随机、自发的升高。以2小时间隔连续呈现同一只雌性小鼠会引发促黄体生成素反应逐渐减弱。然而，将这种无反应的雄性小鼠暴露于新的动情后期雌性小鼠时，会显著刺激它们释放该激素。这些结果表明涉及生殖激素的社会诱导神经内分泌反应出现了习惯化。
