Pirke K M, Fichter M M, Lund R, Doerr P
Acta Endocrinol (Copenh). 1979 Oct;92(2):193-204. doi: 10.1530/acta.0.0920193.
The 24-h sleep-wake pattern of plasma LH was studied in 18 patients with severe weight loss. Sixteen patients had anorexia nervosa, one suffered from schizophrenia and one had a gastric ulcer. The age of the patients ranged from 13 to 31 years. Seventeen women and one boy participated in the study. Their weight ranged from 51 to 73% of the ideal body weight (IBW) at the first 24-h study which was at one week after admission to the hospital. Blood was taken through an indwelling venous catheter every 30 min. The patients' weight increased under behavioural therapy and they were re-studied when they had gained approximately 10% IBW and again prior to release from the psychiatric ward. The LH patterns were classified as infantile, pubertal or adult. All patients except for two had an infantile pattern at the first study. Except for the two patients who had no anorexia nervosa, all developed a pubertal and/or an adult pattern. All patients whose weight was below 69% IBW had an infantile LH pattern. All patients whose weight was below 69% IBW had an infantile LH pattern. Adult patterns were only seen when the body weight was greater than 80% IBW. The increase of the average 24-h LH values was slower the older the patients were and the longer they had been anorectic.
对18例严重体重减轻患者的血浆促黄体生成素（LH）24小时睡眠-清醒模式进行了研究。16例患者患有神经性厌食症，1例患有精神分裂症，1例患有胃溃疡。患者年龄在13至31岁之间。17名女性和1名男性参与了研究。在入院一周后的首次24小时研究中，他们的体重为理想体重（IBW）的51%至73%。通过留置静脉导管每30分钟采集一次血液。患者体重在行为疗法下增加，当体重增加约10%IBW时再次进行研究，并在从精神科病房出院前再次研究。LH模式分为婴儿型、青春期型或成人型。除两名患者外，所有患者在首次研究时均为婴儿型模式。除两名无神经性厌食症的患者外，所有患者均发展为青春期和/或成人型模式。所有体重低于69%IBW的患者均为婴儿型LH模式。所有体重低于69%IBW的患者均为婴儿型LH模式。仅当体重超过80%IBW时才出现成人型模式。患者年龄越大、厌食时间越长，24小时平均LH值的升高就越缓慢。
