Kapen S, Sternthal E, Braverman L
Psychosom Med. 1981 Apr;43(2):177-82. doi: 10.1097/00006842-198104000-00009.
A 32-year-old women with no evidence of anorexia nervosa lost 20 pounds following a self-imposed diet and developed secondary amenorrhea. On two separate occasions, 24-hour plasma sampling at 20-minute intervals the monitoring of nocturnal sleep revealed a "pubertal" pattern of luteinizing hormone (LH) secretion, i.e., sleep-related enhancement of LH. After she regained 15 pounds, the "pubertal" pattern reverted to the typical of adults in which there is no significant difference in LH secretion between average sleep and waking values. One month following the last study, normal menses began. These data demonstrate that weight loss or the metabolic factors associated with nutritional changes, in the absence of anorexia nervosa, may be associated with amenorrhea and reversion to the "pubertal" pattern of LH secretion, which can return to normal following weight gain.
一名32岁无神经性厌食症证据的女性，在自行节食减重20磅后出现继发性闭经。在两个不同的时间段，每隔20分钟进行24小时血浆采样并监测夜间睡眠，发现促黄体生成素（LH）分泌呈“青春期”模式，即与睡眠相关的LH分泌增加。在她体重恢复15磅后，“青春期”模式恢复为成年人的典型模式，即平均睡眠和清醒状态下LH分泌无显著差异。最后一次研究后一个月，月经恢复正常。这些数据表明，在无神经性厌食症的情况下，体重减轻或与营养变化相关的代谢因素可能与闭经以及LH分泌恢复到“青春期”模式有关，体重增加后这种情况可恢复正常。
