Lees G E, McKeever P J, Ruth G R
J Am Vet Med Assoc. 1979 Jul 1;175(1):49-52.
Dapsone was given for six days to a dog with chronic skin disease. The dog then became weak and anorectic, and it vomited and had purpura caused by severe thrombocytopenic hemorrhagic diathesis. Despite treatment, the dog died a week later. There were clinical and pathologic evidence that the dog's platelets and megakaryocytes had been destroyed during the first few days of dapsone therapy. It was concluded that the syndrome was dapsone-induced and that thrombocytopenia should be considered among the adverse reactions to dapsone in the dog.
对一只患有慢性皮肤病的狗给予氨苯砜治疗六天。之后这只狗变得虚弱且食欲不振，出现呕吐，并因严重血小板减少性出血素质而出现紫癜。尽管进行了治疗，这只狗一周后还是死亡了。有临床和病理证据表明，在氨苯砜治疗的最初几天，这只狗的血小板和巨核细胞已被破坏。得出的结论是，该综合征是由氨苯砜引起的，并且在狗对氨苯砜的不良反应中应考虑血小板减少症。
