Le Fur G, Guilloux F, Mitrani N, Mizoule J, Uzan A
J Pharmacol Exp Ther. 1979 Nov;211(2):305-8.
Forcing a rat to swim in a situation from which there is no escape results in an increase in plasma corticosteroid level. This rise was selectively inhibited by benzodiazepines, phenobarbital and meprobamate but not by other psychotropic drugs like trycyclic antidepressants, monoamine oxidase inhibitors, neuroleptics and amphetamines. This effect of benzodiazepines is of central origin since diazepam did not block the rise in plasma corticosteroid level produced by adrenocorticotrophic hormone. Diazepam also had no effect on plasma corticosteroid levels in hypophysectomized rats or in rats treated with betamethasone. Brief stress did not alter binding of [3H]diazepam in vitro nor binding of [3H]flunitrazepam in vivo.
强迫大鼠在无法逃脱的环境中游泳会导致血浆皮质类固醇水平升高。这种升高可被苯二氮䓬类、苯巴比妥和甲丙氨酯选择性抑制，但不能被其他精神药物如三环类抗抑郁药、单胺氧化酶抑制剂、抗精神病药和苯丙胺抑制。苯二氮䓬类的这种作用源于中枢，因为地西泮不会阻断促肾上腺皮质激素引起的血浆皮质类固醇水平升高。地西泮对垂体切除的大鼠或用倍他米松治疗的大鼠的血浆皮质类固醇水平也没有影响。短暂应激不会改变体外[3H]地西泮的结合，也不会改变体内[3H]氟硝西泮的结合。
