Benwell M E, Balfour D J
Psychopharmacology (Berl). 1982;76(2):160-2. doi: 10.1007/BF00435271.
The effects of chronic nicotine administration (0.4 mg/kg for 40 days) and its withdrawal on the adrenocortical response to acute and repeated exposure to stress have been examined and related to changes in brain 5-hydroxyindole levels. No significant effects on the response to acute stress were observed. Repeated exposure to the stressful procedure resulted in complete adaptation of the adrenocortical response and the development of a significant (P less than 0.01) positive correlation between the plasma corticosterone and hippocampal 5-HT concentrations. In nicotine-treated rats, complete adaptation did not occur and the plasma corticosterone showed a significant (P less than 0.05) negative correlation with hippocampal 5-HT. Nicotine withdrawal was not associated with any reduction in plasma corticosterone, but did abolish its relationship with hippocampal 5-HT.
已研究了长期给予尼古丁（0.4毫克/千克，持续40天）及其戒断对肾上腺皮质对急性和反复应激暴露反应的影响，并将其与脑5-羟色胺水平的变化相关联。未观察到对急性应激反应有显著影响。反复暴露于应激程序导致肾上腺皮质反应完全适应，并且血浆皮质酮与海马5-羟色胺浓度之间出现显著（P小于0.01）正相关。在尼古丁处理的大鼠中，未发生完全适应，血浆皮质酮与海马5-羟色胺呈显著（P小于0.05）负相关。尼古丁戒断与血浆皮质酮的任何降低均无关，但确实消除了其与海马5-羟色胺的关系。
