Sophasan S, Saraggananda B
Pflugers Arch. 1979 Aug;381(2):165-9. doi: 10.1007/BF00582348.
Renal blood flow (RBF) in rat was measured by using a noncannulating electromagnetic flowmeter. In the sham control rats, anesthetized with Inactin, RBF averaged 7 ml/min/g KW when arterial blood pressure was above 110 mm Hg. Autoregulation of RBF was observed when the arterial blood pressure was in the range of 110-150 mm Hg. Glomerular filtration rate (GFR), measured by polyfructosan clearance, averaged 1.08 ml/min/g KW. In experimental rats with 24 h of bilateral ureteral ligation (BUL), RBF averaged 38% of control value. During 1/2-3 h following release of the left ureteral occlusion, RBF increased to 60% of control value. The autoregulatory ability of the damaged kidney was reduced during BUL and did not improve after releasing occlusion. During the post-obstructive period arterial blood pressure remained stable. Thus, a high total renal vascular resistance was responsible for the depressed RBF. GRF in these rats averaged only 9% of control value. The reduction in RBF alone does not explain the drastic reduction in GFR in this model of renal failure.
采用非插管式电磁流量计测量大鼠肾血流量（RBF）。在使用安泰酮麻醉的假手术对照大鼠中，当动脉血压高于110 mmHg时，RBF平均为7 ml/min/g体重。当动脉血压在110 - 150 mmHg范围内时，观察到RBF的自身调节。通过聚果糖清除率测量的肾小球滤过率（GFR）平均为1.08 ml/min/g体重。在双侧输尿管结扎（BUL）24小时的实验大鼠中，RBF平均为对照值的38%。在解除左侧输尿管梗阻后的1/2 - 3小时内，RBF增加至对照值的60%。在BUL期间，受损肾脏的自身调节能力降低，解除梗阻后也未改善。在梗阻后期间，动脉血压保持稳定。因此，高总肾血管阻力是导致RBF降低的原因。这些大鼠的GRF平均仅为对照值的9%。在这种肾衰竭模型中，仅RBF的降低并不能解释GFR的急剧下降。
